19 of the Russian's twenty-one titles have been achieved on hard surfaces
A comeback the Russian player won his maiden trophy for 882 days with a win over Corentin Moutet in the Almaty Open championship match.
Medvedev, a former number one, has endured a torrid year, managing just one match at the Grand Slams and experiencing a meltdown at the American major.
His varied form on the ATP Tour - and difficulties with his serve in specific - caused him dropping out of the world's top 10 and ultimately separating with former coach his previous coach.
Now working with Thomas Johansson and Goetzke, Medvedev has gradually advanced in the recent weeks - climaxing in a closely contested competitive win over opponent Corentin Moutet.
It is his maiden championship following the Italian tournament and first on a hard court from spring of 2023.
Success also means Medvedev has achieved twenty-one championships at 21 distinct tournaments.
"This marks the first occasion I have attended a competition with my both daughters simultaneously, so to win a championship is really nice," said world number 14 the champion.
"This championship is in honour of my child Victoria, because the initial championship I won when my child my daughter was delivered was for her."
Medvedev, the former major winner, had been defeated in his past six finals, including in the German tournament in the past months.
The player's defensive approach and recurring outbursts on the playing surface had prompted observers to question if his skill to play at the highest level was finished.
Yet the athlete has made changes in recent weeks, attempting to come to the net and perform aggressively, reinforced by an improved serve.
He fought back from a break down in the first set against the tricky Frenchman, taking four of the last five games to take the lead.
Both players traded breaks in the middle set before the Frenchman, attempting for his maiden tour championship, gained dominance to force a final set.
He saved four early opportunities in a close deciding set before the Russian secured a break to 15 to close out the victory.
Appropriately, the winner secured the title with a shot at the net area, with his opponent unable to control a return after over two and a half hours.
